Intestinal resolution: helminth parasite clearance through selenoproteins
نویسندگان
چکیده
منابع مشابه
Vaccination against helminth parasite infections.
Helminth parasites infect over one fourth of the human population and are highly prevalent in livestock worldwide. In model systems, parasites are strongly immunomodulatory, but the immune system can be driven to expel them by prior vaccination. However, no vaccines are currently available for human use. Recent advances in vaccination with recombinant helminth antigens have been successful agai...
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Blastocystis hominis is a worldwide distributed microorganism with no definite host. In addition to human beings it has been diagnosed in variety of animals. This organism which is abundantly found in routine stool examinations and also 'in some cases has been identified as a factor causing severe diarrhea, earlier regarded as a fungi. Later it was distinguished as cyst of intesinal Trichomonas...
متن کاملCounter-regulatory anti-parasite cytokine responses during concurrent Plasmodium yoelii and intestinal helminth infections in mice.
Malaria and helminth infections are two of the most prevalent parasitic diseases globally. While concomitant infection is common, mechanisms contributing to altered disease outcomes during co-infection remain poorly defined. We have previously reported exacerbation of normally non-lethal Plasmodium yoelii malaria in BALB/c mice chronically infected with the intestinal trematode Echinostoma capr...
متن کاملAssessing the Role of CD103 in Immunity to an Intestinal Helminth Parasite
BACKGROUND In the intestine, the integrin CD103 is expressed on a subset of T regulatory (T(reg)) cells and a population of dendritic cells (DCs) that produce retinoic acid and promote immune homeostasis. However, the role of CD103 during intestinal helminth infection has not been tested. METHODOLOGY/PRINCIPAL FINDINGS We demonstrate that CD103 is dispensable for the development of protective...
متن کاملAccessing human selenoproteins through chemical protein synthesis.
The human body contains 25 selenoproteins, which contain in their sequence the twenty-first encoded amino acid, selenocysteine. About a dozen of these proteins remain functionally uncharacterized or poorly studied. Challenges in accessing these selenoproteins using traditional recombinant expressions have prevented biological characterization thus far. Chemical protein synthesis has the potenti...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2013
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.27.1_supplement.860.10